Photodynamic Therapy and Skin Appendage Disorders: A Review

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چکیده

Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonneoplastic dermatological diseases. The present review summarizes published data on PDT application in skin appendage disorders. Our literature review shows that: (a) PDT may be a suitable treatment for acne, folliculitis decalvans, hidradenitis suppurativa, nail diseases, and sebaceous hyperplasia; (b) there is a lack of agreement on PDT features (type, concentrations and incubation period of used substances, number and frequency of PDT sessions, optimal parameters of light sources, and patient characteristics [e.g., failure to previous treatments, disease severity, body surface area involved, etc.] which should guide PDT use in these diseases); (c) further research is needed to establish international guidelines helping dermatologists to choose PDT for the right patient at the right time. © 2016 S. Karger AG, Basel Received: September 28, 2016 Accepted: November 7, 2016 Published online: December 8, 2016 Matteo Megna, MD Section of Dermatology, Department of Clinical Medicine and Surgery University of Naples Federico II Via Pansini 5, IT–80131 Naples (Italy) E-Mail mat24 @ libero.it © 2016 S. Karger AG, Basel 2296–9195/16/0024–0166$39.50/0

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تاریخ انتشار 2016